Department of Obstructive and Genecology, College of Medicine, University of Kufa, Kufa, Iraq
Research
The impact of adding estradiol to progesterone in luteal phase support in patients with in vitro fertilization
Author(s): Amal Muner Mubarak*, Aseel Abdulameer Mohammed, Dalal M Jarrah and Zahraa F. Alhilli
Background: Luteal phase support (LPS) after ICSI is a critical step, with progesterone being the standard treatment. However, the benefit of adding estradiol to this support remains controversial.
Objective: To evaluate the effect of adding oral estradiol to progesterone for luteal phase support in patients undergoing ICSI/ET.
Design: Prospective cohort study.
Setting: Fertility Center, Alsader Teaching Hospital, Najaf.
Patients and methods: A total of 180 subfertile women aged 18-35 years, undergoing ovarian stimulation and ICSI, were randomly divided into two groups for luteal phase support. The progesterone-only group (n=90) received vaginal progesterone (400 mg twice daily) and oral dydrogesterone (20 mg daily). The progesterone plus estradiol group (n=90) r.. Read More»