Dr, Departments of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt
Research
Renalase gene polymorphism (rs2576178 and rs10887800) in non severe and severe pre-eclamptic egyptian females
Author(s): Shimaa Sabry Abd El Ghany*, Nermine Helmy Mahmoud, Azza Abd El Rahman Saab, Mohamed Ahmed Hassan El Kadi and Doaa Mostafa Awad
Background: Pre-eclampsia (PE) is a fatal disease for both mother and fetus diagnosed by criteria of ACOG 2017. Gene polymorphisms as renalase gene rs10887800 and rs2576178 are proposed for early prediction and prognosis of PE. This study aimed at assessing the relation between renalase gene polymorphism and development of PE as well as the severity of the disease.
Subjects and Methods: This case-control study included 40females (group I) with PE further subdivided into group Ia 20 non severe PE, group Ib 20 severe PE and group II 20 healthy controls. Renalase gene polymorphisms assessed by PCR-RFLP and confirmed by gene sequencing.
Results: Our results found Renalase rs10887800 homozygous GG& heterozygous AG genotype in 67.5% of PE females compared with 20% in controls, while AA(wild genotype) was found&n.. Read More»