Abstract
Author(s): Wisam Hashim Baqer, Ali A. Obais, Entsar Hadi Jawad and Saif M. Hassan*
Introduction: While Radiation Therapy (RT) uses high-energy radiation to kill cancer cells, concurrent Chemoradiotherapy (CCRT) is the application of chemotherapy with radiation treatment. Late toxicities are long-term side effects perhaps occurring months or even years after therapy ends.
Method: Linked to CCRT and RT alone, a retrospective analysis aimed to evaluate the risk of acute and late toxicities in women With Non-Small Cell Lung Cancer (NSCLC). Among the immediate toxicity were leukopenia, hepatic and renal failure, nausea and vomiting, and neutropenia.
Results: Acute Toxicity; the CCRT group had much more occurrences of neutropenia than the RT group; rates of nausea and vomiting were also much higher in the CCRT group. Compared to acute CCRT and acute RT toxicities, both late CCRT and late RT toxicities displayed rather higher incidence of severe neutropenia, nausea and vomiting.
Conclusion: Our study shows that CCRT is more likely than radiation treatment to cause late-stage severe toxicity. Moreover, for both CCRT and RT, the significance of late toxicities especially late severe ones is stressed. These findings coincide with the given claim.