Abstract
Author(s): Roua ShhabâAldeen Ahmed*, Nadia Mohammed Mahdi Al-Shakir, Abd Algabar, Fatima Amer, Al-Azzam A.H. Maanee
Background: Polycystic ovary syndrome (PCOS) is a widespread problem among women lived in Baghdad city in terms of its thorny relationship with insulin resistance, which is a relational element with the case of infection with the Helicobacter pylori bacteria in the same women. The phenomenon of insulin resistance and the health problems that follow it has become a matter of concern for Iraqi women who suffer from polycystic ovary syndrome and who have been diagnosed with Helicobacter pylori. Objective: This study determined the effect of Helicobacter pylori infection on insulin resistance in a group of women with polycystic ovary syndrome (PCOS). Methods: Cases were collected at Kamal Al-Samarrai hospital for infertility. The total number of Cases was 130 divided into 90 PCOS and 40 control from the staff of the hospital. Biochemical and immunological parameters of Fasting Blood Sugar (mg/dL), Insulin (mIU/L), HOMA-IR and Cytotoxin-binding antibodies (CagA_IgG) were used to find the effects of Helicobacter pylori infection on insulin resistance in PCOS patients. Results: The results of this study observed the number of PCOs female groups who treated with metformin gave positive CagA-IgG (≥0.4) results were 26/40 (47.3%) versus 29/50 (52.7%) of those who not treated with metformin in comparing with control groups with no cases had positive results, Statistically these differences were highly significant (P-value ≤ 0.0001). The data reveals that both the untreated and treated groups exhibit significantly elevated levels of fasting blood sugar (F.B.S), insulin, and insulin resistance (IR) when compared to the control group. However, the untreated group displays the highest levels for all these parameters. Conclusion: The most cases of PCOs were obese and overweight BMI (Kg/m2) among the untreated (not taken metformin treatment) groups, observed the number of PCOs female groups who treated with metformin had positive cagA-IgG. Both insulin levels and insulin resistance are markedly elevated in female with positive CagA-IgG status in both treated and untreated groups; this indicates a possible association between CagA-IgG positivity and metabolic disturbances, especially concerning insulin regulation and resistance.