Abstract
Author(s): Karrar Sadeq Khudhair*, Estabraq Kwaeri Al-Wasiti, Anees K. Nile, Ammar S. Al Khafaji, Baneen Ali Naji
Background: Obesity is a chronic and debilitating disease that has become a global epidemic. People who are obese have increased morbidity, mortality and reduced life expectancy (LE) when compared to those with healthy weight. The medical therapy has achieved great progress. However, many patients still exposed to the complications of the disease. Laparoscopic sleeve gastrectomy (LSG) causes weight loss and metabolic improvement. While Liposuction (LS) is the most commonly performed cosmetic surgical procedure worldwide. Matrix metalloproteinases (MMPs) are involved in physiological and pathological complications of obesity or metabolic syndrome through the degradation and remodeling of the extracellular matrix (ECM) molecules. Leptin and ghrelin play a significant role on the energy balance, food intake and body weight regulation. Objectives: Measure the levels of lipid profile and BMI before and after Liposuction and laparoscopic sleeve gastrectomy in obese women. Methods A case study of 40 women with age range (18-60 years) was included in this study and the BMI more than 30 kg/m2. All surgeries were performed by the different team and were completed as scheduled according to the standard protocols. All patients were scheduled to return for a follow-up visit with their surgeon one month. Follow-up evaluations included estimation of lipid profile. Results: After one month for both LSG and LS the result observed there were high significantly differences between the LSG and LS in BMI before and after operation respectively (44.27±5.36 kg/m2 vs. 32.93±3.48 kg/m2, 39.9315±5.123, 31.557±3.314 kg/m2) (p=0.0001). In current study the level of cholesterol, TG, LDL and VLDL there were decrease significantly in LSG but no significant difference in level of these parameters in LS. While there was no significant difference in HDL level in both LSG and LS. The correlation between parameters in post-LSG revealed a positive correlation between BMI and MMP-9 concentration, total cholesterol with LDL, TG with VLDL and leptin with MMP-9 concentration when compared with post LS that showing a positive correlation between BMI with MMP-9 concentration, total cholesterol with HDL and LDL, TG with VLDL, ghrelin with VLDL and leptin with MMP-9 concentration. Conclusion: From the result of the current study the LSG have a highly effective treatment for obese women to loss body weight in contrast with LS, because the LS consider as a cosmetic surgery and have a localized effective of the body.