Abstract
Author(s): Hanan Najdi Kadhim*, Ghosoun Ghanem Kaem and Hameedah Hadi Abdulwahid
Background: Premature Ovarian Insufficiency (POI) is a clinical disease characterized by an early decline in ovarian function that results in a persistent hypo-estrogenic state in women under the age of 40 years. It is distinguished by decreased ovarian follicles and insufficient ovarian sex hormones, which hasten the menopause.
Objective: Investigate the relationship between Premature Ovarian Insufficiency (POI) and bones health).
Methods: 100 women participated in a case control study,50 patients and 50 control,5ml of blood samples was collected then serum separated used to measure levels of Collagen1, Bone-specific Alkaline Phosphatase(BALP), Anti-Mullerian Hormone(AMH),Vitamin D3, serum Calcium Ca+2 using an enzyme-linked immunosorbent assay and chemiluminescent automated immunoassay system (ECL).
Results: According to results of this study there was significantly decreased in Collagen, Bone-specific Alkaline Phosphatase (BALP), Anti-Mullerian Hormone (AMH), Vitamin D3, serum Calcium Ca+2 levels in patients groups of POI) in contrast to control group.
Conclusion: There were negative effects of POI on bones health.