Abstract
Author(s): JOANNA HOÅODY-ZARÄBA, PIOTR KINALSKI, MACIEJ KINALSKI
ntroduction. Endometrial cancer is one of the most common malignancies in women. In Polandduring the ill 11,9 per 100 thousand. women, and 2.4 per 100 thousand die. women.The Aim.The evaluation assessed the prevalence of risk factors for endometrial cancer. Testsperformed in a group of women with endometrial cancer and in the control group of womenwho did not have the above pathology. We compared the occurrence of the factors such asage, body weight, number of births, age of first and last menstrual period, t 2 diabetes inci-dence and hypertension, treatment with tamoxifen, the use of Hormone Replacement Therapy(HRT).Material and methods. The study group consisted of women patients were hospitalized in theDepartment of Gynaecology and Obstetrics Regional Hospital in Bialystok in 2008-2011 who underwent uterine curettage or hysteroscopy was performed. The indication for surgery wasirregular vaginal bleeding and / or abnormal endometrial image transvaginal ultrasound. Basedon medical records provided information on age, weight, number of births, age of first andlast menstrual period, the incidence of t 2 diabetes and high blood pressure, treatment withtamoxifen, the use of HRT. The study population of women were divided into two groups. Thefirst group consisted of 124 patients with diagnosed and documented by histological study ofpost-operative endometrial cancer. The control group consisted of 114 patients, in whompathological material, there was no change in endometrial cancer.Results. Patients in the group with endometrial cancer were between the ages of 37 to 88 yearsMean age was 62.9.In the control group, the oldest patient was 87 years old and the youngest38. The average age in this group was 56.0. The average age of patients in group with en-dometrial cancer in comparison with the average age of the control group was significantlyhigher (p <0.05). The value of BMI, age of menopause, presence of hypertension, the use ofHRT and tamoxifen in patients with endometrial cancer compared to the control group sho-wed a statistically significant difference. However, in the analysis of age of menarche, numberof births and the incidence of diabetes t 2 no statistically significant difference between thetwo groups. Additionally the co-existence of t 2 diabetes and obesity in both group. In com-parative evaluation, no statistically significant difference was observed.Conclusions. Obesity, late menopause, hypertension, treatment with tamoxifen occurred signi-ficantly more often in women with endometrial cancer. Factors that did not affect the deve-lopment of endometrial cancer in women was age of menarche, number of births, and type2 diabetes. It was confirmed that the use of estrogen-progesterone therapy worked condescen-dingly on the endometrium.