Abstract
Author(s): Widad Abd AL-Jabbar*, Yasmeen Ali Hussein, Saad Mashkoor Waleed, Nada Abdulhur Abed Alibraheemi, Najah R. Hadi
Background: Up to ninety percent of pregnant mothers experience nausea and vomiting in pregnancy (NVP) which is the most prevalent medical condition during pregnancy. Hyperemesis gravidarum (HG), a severe prognosis form of nausea and vomiting, affects 0.3% to 3.6% of pregnant mothers in the world. HG is lead to fetal and maternal morbidity as well as nutritional deficiencies during pregnancy period in addition to its effect on mentality, injury to oesophagous, and birth abnormalities such as premature delivery, low birth weight. The purpose of the present research is to assessing the safety of doxylamine & pyridoxine combination in nausea and vomiting in pregnancy compared to B6 only. Patients and methods: One hundred fifty pregnant women suffering from nausea and vomiting during pregnancy were enrolled in this study. Randomized divided into two groups, group 1 (n= 75) receive (doxylamine and B6) and group 2 (n= 75) receive B6 only for 15 days with a dosages varying from 2–4 tablets \ day, Pregnancy-Unique Quantification of Emesis and Nausea (PUQE) score were assessed at 0 time and at three, six, fifteen day of study, blood samples were collected at 0, and 15 day of study for determination of Ferritin & potassium level. Results: Doxylamine 10 mg and pyridoxine 10mg (B6) use has a good effect in controlling N&V in pregnancy over B6 only. Conclusions: Doxylamine–pyridoxine together is well absorbed in pregnancy and very safe specially when taken as a prescribed dose of up to four tablets per day for treating nausea and vomiting during pregnancy.