Abstract
Author(s): JarosÅaw von Mach SzczypiÅski, StanisÅaw Stanosz, Ewa Å»ochowska, Jakub KoÅciuszkiewicz
Introduction. Premenopausal syndrome is a neurohormonal disorder characterized by general, mental and somatic symptoms. Aim. Assessment of serum levels of: follicle-stimulating hormone (FSH), luteinizing hormone (LH), estrone (E1), estradiol (E2), progesterone (P), prolactin (PRL), dopamine (DA) and serotonin (5-HT) in perimenopausal women depending on the place of residence. Material and methods. The study included 269 pluriparas in the perimenopausal age. The patients were divided into groups depending on their place of residence. In both groups, clinical, biophysical and biochemical examinations were conducted to determine gonadotropin, estrogen, prolactin, dopamine and serotonin levels using immunoenzymatic methods with a kit by IBL. Results. The women residing in urban areas had significantly higher levels of LH, estrogens, prolactin and serotonin as well as significantly lower levels of dopamine and progesterone. These levels, with the exception of LH and serotonin, normalized after modified hormone replacement therapy. Conclusion. An increased LH level, relative hyperestrogenism, hyperprolactinemia and hyperserotoninemia in women residing in urban areas can indicate the development of polycystic ovary syndrome.