Abstract
Author(s): Aya Hussein Athab*, Alaa Hussein Al-Safy and Kiaser Abdulsajjad M. Hussain
Background: Introduction: Ashwagandha has anti-inflammatory, immunomodulatory and antibacterial properties. It has been demonstrated that parabens, which are used as preservatives in many food products, have negative effects. In addition, plant-based phytoparticles have been shown to exhibit nanomaterials with non-toxic, clean and environmentally friendly methods. This has attracted interest from researchers due to the outstanding properties of nanotechnology.
Method: A total of 24 female albino rats were divided into four groups: The control group, the paraben group, the Ag-Nano group and the combination group. Blood samples were taken from each animal for WBC, Hb and hormonal tests at the end of the experiment.
Results: Paraben preservatives significantly increased haemoglobin levels, but showed a nonsignificant decrease in white blood cells. There was a significant decrease in both estrogen and progesterone levels compared to the control. The nano-particles treated group showed no significant difference in haemoglobin and estrogen, while there was a significant increase (P<0.05) in WBC and PR levels compared to the control. The combination group showed No significant difference in haemoglobin, white blood cells, but there was a significant increase (P<0.05) in both estrogen and progesterone levels compared to the control.
Conclusion: The nano-particles treated group had no significant difference in levels of haemoglobin and estrogen compared to the control, but it showed a significant increase in WBC and PR levels (P<0.05). The combination group had no significant difference in haemoglobin and white blood cells, but there was a significant increase in both estrogen and progesterone levels (P<0.05) compared to the control.