Abstract
Author(s): Khawla I. Abd Nusaif, Kawther Mejbel Hussein*, Sara Abdalkareem Moshref, Inam Joudah Radhi
Background: The anterior pituitary gland secretes two hormones that are important for controlling the reproductive processes of females: follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Objective: Studying the relationship between obesity and serum SHBG, LH, and FSH levels as a predictive marker in infertility patients from AL-Najaf governorate/ Iraq. Patients and Methods: We used 120 samples of Iraqi women in the 25–40 age range. Sixty well-diagnosed infertility patients and sixty healthy fertile women made up the control group in an age-matched case-control study. The groups are gathered between May 2024 to October 2024 from Al-Zahraa Hospital in the Najaf governorate. An enzyme-linked immunosorbant assay (ELISA) was used to test each subject's hormonal metabolism and hirsutism scores. The results were analyzed with appropriate statistical methods. Results: The BMI, LH, LH/FSH ratio, TT, FAI, FIN, FSG, and HOMA-I R values of the infertility patient women were considerably greater than those of the healthy women group. Conclusion: The current findings indicate that elevated levels of LH and FSH in women with infertility are associated with hyperandrogenism and insulin resistance, which serve as predictors of fibroblast and endothelial cell dysfunction as well as metabolic problems. This research discusses the relationship between SHBG and infertility, as well as associated hormonal levels.